The engineered NK cells are then expanded at scale to generate an abundant supply of doses. To produce NKX101, NK cells obtained from the peripheral blood of healthy donors are engineered with membrane-bound interleukin 15 and a chimeric antigen receptor (CAR) to enhance the targeting and killing of tumour cells. NKX101 is an “off-the-shelf” investigational immunotherapy currently in a Phase I clinical trial for patients with relapsed/refractory acute myeloid leukemia (AML) or higher-risk myelodysplastic syndromes (MDS). As part of this collaboration, GBF will continue to manufacture NKX101, Nkarta’s clinical stage investigational NK cell therapy, in its facility on the University of Colorado Anschutz Medical Campus in Aurora, Colorado. The Gates Biomanufacturing Facility (GBF) has announced a continued strategic agreement with Nkarta to manufacture clinical supply of therapeutic natural killer cells.
